Linezolid safety, tolerability and efficacy to treat multidrug- and extensively drug-resistant tuberculosis.

respiratory muscles. Thus, the associated perceived effort required to generate a given ventilation during exercise is similarly reduced. The deeper, slower breathing pattern after radiation therapy and delay in the onset of tachypnoea reflect the recruitment of IC both at rest and during exercise as a result of lung volume deflation. Thus, the patient could increase tidal volume and ventilation during exercise to a greater extent than previously, before reaching critical mechanical constraints. For this reason, the onset of intolerable dyspnoea was delayed and the limits of tolerance extended.